Fundamental studies on combined effect by flucytosine and amphotericin B.
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of amphotericin B and flucytosine.
The absorption of flucytosine from the digestive tract is very good but minimal with amphotericin B. For this reason, amphotericin B has to be injected intravenously. Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin B, since the dose has to be increased slowly. Distribution of flucytosine in other body fluids is high, whereas with amphotericin B it is poor. ...
متن کاملCombined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections.
Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily...
متن کاملA comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptoccal meningitis.
We compared amphotericin B therapy for cryptococcal meningitis with a newer regimen containing both amphotericin B and flucytosine. In 50 patients with 51 courses of therapy adherent to the protocol, 27 courses were with amphotericin B and 24 with the combination. Even though the combination regimen was given for only six weeks and amphotericin B for 10 weeks, the combination cured or improved ...
متن کاملPharmacokinetics of amphotericin B and flucytosine ANNEMARIE POLAK
The absorption of flucytosine from the digestive tract is very good but minimal with amphotericin B. For this reason, amphotericin B has to be injected intravenously. Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin B, since the dose has to be increased slowly. Distribution of flucytosine in other body fluids is high, whereas with amphotericin B it is poor. ...
متن کاملFlucytosine and Amphotericin B Coadministration Induces Dose-Related Renal Injury
Invasive fungal infections remain an important clinical problem, and despite recent approaches, they bring high morbidity and mortality. Combination therapies are the most effective; however, adverse effects need to be considered. In this study, we aimed to evaluate the nephrotoxicity induced by combined therapy of flucytosine (FL) and amphotericin B (AMF) at 3 different doses administered to m...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Mycology
سال: 1984
ISSN: 1884-6971,0583-0516
DOI: 10.3314/jjmm1960.25.125